What the FDA labels say about taking them together
Drospirenone/ethinyl estradiol and lamotrigine
Drospirenone/ethinyl estradiol's FDA label of May 29, 2025 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name drospirenone/ethinyl estradiol. The drospirenone/ethinyl estradiol label: “COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.”
Check it at the source: the drospirenone/ethinyl estradiol FDA label on DailyMed (effective May 29, 2025, Bayer HealthCare Pharmaceuticals Inc.); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the drospirenone/ethinyl estradiol label say about lamotrigine?
Drospirenone/ethinyl estradiol label, drug interactionsCOCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.
Source: FDA drug label (Yaz), Bayer HealthCare Pharmaceuticals Inc., effective May 29, 2025 (SPL set 065f33e4-b587-4e66-b896-ca9ab7b7c876), via openFDA; the full label on DailyMed
What does the lamotrigine label say about drospirenone/ethinyl estradiol?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name drospirenone/ethinyl estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Drospirenone/ethinyl estradiol | Lamotrigine | |
|---|---|---|
| Labeled for | Acne, Birth control | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.151 per tablet 3-0.03 mg tablet | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once