Drospirenone and Lamotrigine Interaction
Drug interaction information between Drospirenone and Lamotrigine.
Drospirenone and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Drospirenone and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The birth control pill makes your body get rid of lamotrigine much faster than usual. This can lower the amount of medicine in your blood and make it less effective at preventing seizures.
FDA Label Information
COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation. This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary.
Drospirenone Also Interacts With
- Estradiol major
- Atorvastatin minor
- Omeprazole minor
- Topiramate minor
- Tizanidine minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Drospirenone/Ethinyl Estradiol + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Drospirenone has 30 labeled pairs on file vs Lamotrigine's 24. In the minor band specifically: Drospirenone has 29 (also Atorvastatin, Omeprazole, Topiramate, Tizanidine); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Drospirenone/Ethinyl Estradiol and Lamotrigine?
The birth control pill makes your body get rid of lamotrigine much faster than usual. This can lower the amount of medicine in your blood and make it less effective at preventing seizures.
Drospirenone carries more major-labeled pairs than Lamotrigine
SPL source-record counts only. This page's band is minor · classes on file: Drospirenone (Combined Oral Contraceptive); Lamotrigine (Anticonvulsant).
Drospirenone has 1 major-labeled pair vs Lamotrigine's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 29 minor · 30 total
- Other minor peers for Drospirenone
- Atorvastatin
- Omeprazole
- Topiramate
- Tizanidine
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.