Drospirenone and Atorvastatin Interaction
Drug interaction information between Drospirenone and Atorvastatin.
Drospirenone and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Drospirenone and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking atorvastatin can cause the level of estrogen from your birth control pill to increase in your body.
FDA Label Information
Substances Increasing the Plasma Concentrations of COCs Co-administration of atorvastatin and certain COCs containing EE increase AUC values for EE by approximately 20%.
Drospirenone Also Interacts With
- Estradiol major
- Omeprazole minor
- Lamotrigine minor
- Topiramate minor
- Tizanidine minor
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Drospirenone/Ethinyl Estradiol + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Drospirenone's 30. In the minor band specifically: Drospirenone has 29 (also Omeprazole, Lamotrigine, Topiramate, Tizanidine); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Drospirenone/Ethinyl Estradiol and Atorvastatin?
Taking atorvastatin can cause the level of estrogen from your birth control pill to increase in your body.
Atorvastatin carries more major-labeled pairs than Drospirenone
SPL source-record counts only. This page's band is minor · classes on file: Drospirenone (Combined Oral Contraceptive); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Drospirenone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 29 minor · 30 total
- Other minor peers for Drospirenone
- Omeprazole
- Lamotrigine
- Topiramate
- Tizanidine
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.