Drospirenone and Omeprazole Interaction
Drug interaction information between Drospirenone and Omeprazole.
Drospirenone and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Drospirenone and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The birth control pill slows down how your body breaks down omeprazole. This can cause the level of omeprazole in your blood to rise slightly.
FDA Label Information
COCs Increasing the Plasma Concentrations of CYP450 Enzymes In clinical studies, administration of a hormonal contraceptive containing EE did not lead to any increase or only to a weak increase in plasma concentrations of CYP3A4 substrates (e.g., midazolam) while plasma concentrations of CYP2C19 substrates (e.g., omeprazole and voriconazole) and CYP1A2 substrates (e.g., theophylline and tizanidine) can have a weak or moderate increase.
Drospirenone Also Interacts With
- Estradiol major
- Atorvastatin minor
- Lamotrigine minor
- Topiramate minor
- Tizanidine minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Drospirenone/Ethinyl Estradiol + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Drospirenone has 30 labeled pairs on file vs Omeprazole's 27. In the minor band specifically: Drospirenone has 29 (also Atorvastatin, Lamotrigine, Topiramate, Tizanidine); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Drospirenone/Ethinyl Estradiol and Omeprazole?
The birth control pill slows down how your body breaks down omeprazole. This can cause the level of omeprazole in your blood to rise slightly.
Drospirenone's labeled portfolio outnumbers Omeprazole
SPL source-record counts only. This page's band is minor · classes on file: Drospirenone (Combined Oral Contraceptive); Omeprazole (Proton Pump Inhibitor (PPI)).
1 major · 0 moderate · 29 minor · 30 total
- Other minor peers for Drospirenone
- Atorvastatin
- Lamotrigine
- Topiramate
- Tizanidine
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.