Drospirenone and Estradiol Interaction
Drug interaction information between Drospirenone and Estradiol.
Drospirenone and Estradiol have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Drospirenone and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Drospirenone can cause your body to keep too much potassium, and taking it with other similar drugs can make this effect stronger.
FDA Label Information
Potential to Increase Serum Potassium Concentration There is a potential for an increase in serum potassium concentration in women taking drospirenone, ethinyl estradiol and levomefolate calcium tablets and levomefolate calcium tablets with other drugs that may increase serum potassium concentration [see Warnings And Precautions ( 5.2 ) and And Clinical Pharmacology ( 12.3 )]. 7.3 Concomitant Use with HCV Combination Therapy – Liver Enzyme Elevation Do not co-administer drospirenone, ethinyl estradiol and levomefolate calcium tablets and levomefolate calcium tablets with HCV drug...
Drospirenone Also Interacts With
- Atorvastatin minor
- Omeprazole minor
- Lamotrigine minor
- Topiramate minor
- Tizanidine minor
Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Drospirenone/Ethinyl Estradiol + Estradiol?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Drospirenone's 30. In the major band specifically: Drospirenone has 1; Estradiol has 1.
What mechanism field is on file for Drospirenone/Ethinyl Estradiol and Estradiol?
Drospirenone can cause your body to keep too much potassium, and taking it with other similar drugs can make this effect stronger.
Estradiol's labeled portfolio outnumbers Drospirenone
SPL source-record counts only. This page's band is major · classes on file: Drospirenone (Combined Oral Contraceptive); Estradiol (Estrogen Hormone).
1 major · 0 moderate · 29 minor · 30 total
Drospirenone has no other major-band peer in this dataset besides Estradiol.
1 major · 3 moderate · 50 minor · 54 total
Estradiol has no other major-band peer in this dataset besides Drospirenone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.