Drospirenone and Topiramate Interaction
Drug interaction information between Drospirenone and Topiramate.
Drospirenone and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Drospirenone and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate causes your body to process birth control hormones faster than normal. This can make the birth control pill less effective at preventing pregnancy.
FDA Label Information
Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St.
Drospirenone Also Interacts With
- Estradiol major
- Atorvastatin minor
- Omeprazole minor
- Lamotrigine minor
- Tizanidine minor
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Drospirenone/Ethinyl Estradiol + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Drospirenone and Topiramate tie at 30 labeled pairs each. minor-band counts: Drospirenone 29 alongside Atorvastatin, Omeprazole, Lamotrigine, Tizanidine; Topiramate 27 alongside Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine.
What mechanism field is on file for Drospirenone/Ethinyl Estradiol and Topiramate?
Topiramate causes your body to process birth control hormones faster than normal. This can make the birth control pill less effective at preventing pregnancy.
Drospirenone carries more major-labeled pairs than Topiramate
SPL source-record counts only. This page's band is minor · classes on file: Drospirenone (Combined Oral Contraceptive); Topiramate (Anticonvulsant).
Drospirenone has 1 major-labeled pair vs Topiramate's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 29 minor · 30 total
- Other minor peers for Drospirenone
- Atorvastatin
- Omeprazole
- Lamotrigine
- Tizanidine
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.