Sotalol and Fluoxetine Interaction
Drug interaction information between Sotalol and Fluoxetine.
Sotalol and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sotalol and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines can both affect your heart's rhythm. Using them together might make heart rhythm problems more likely.
FDA Label Information
These include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Sotalol + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Sotalol's 13. In the minor band specifically: Sotalol has 9 (also Albuterol, Diltiazem, Verapamil, Clozapine); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Sotalol and Fluoxetine?
These medicines can both affect your heart's rhythm. Using them together might make heart rhythm problems more likely.
Fluoxetine carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is minor · classes on file: Sotalol (Class III Antiarrhythmic / Beta-Blocker); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Sotalol's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 9 minor · 13 total
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.