fluoxetine vs sotalol
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Side-by-side comparison of fluoxetine and sotalol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
These include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).
Prozac, Sarafem
Betapace
Fluoxetine is a medicine that can help treat depression and other mental health conditions. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Sotalol is a medicine that helps keep your heart beating regularly. It can treat dangerous fast heartbeats and help prevent irregular heartbeats from coming back.
Fluoxetine can treat major depressive disorder in adults and children. It also treats obsessive-compulsive disorder (OCD) in adults and children. Fluoxetine can help with bulimia nervosa (an eating disorder) and panic disorder. Sometimes, it is used with another medicine called olanzapine to treat depression related to bipolar disorder.
Sotalol is used to treat life-threatening fast heartbeats in the lower chambers of the heart. It is also used to help keep a normal heart rhythm in people with atrial fibrillation or flutter, which are types of irregular heartbeats in the upper chambers of the heart. Sotalol is for people who have very bothersome symptoms from their atrial fibrillation or flutter.
Fluoxetine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluoxetine can help improve mood and reduce symptoms of depression, OCD, and other conditions.
Sotalol works by slowing down the electrical signals in your heart. It has two actions: it blocks beta receptors (like a beta-blocker) and it prolongs the action potential duration in the heart. This helps to stabilize your heart rhythm and prevent irregular heartbeats.
- • Abnormal dreams
- • Problems ejaculating
- • Loss of appetite
- • Feeling anxious
- • Feeling weak
- • Feeling tired
- • Slow heart rate (less than 50 bpm)
- • Shortness of breath
- • New or worsening irregular heartbeats
- • Weakness
- Drug Interaction 3,335
- Toxicity To Various Agents 3,316
- Nausea 3,233
- Fatigue 3,156
- Completed Suicide 2,904
- Atrial Fibrillation 1,179
- Dyspnoea 912
- Fatigue 868
- Dizziness 734
- Diarrhoea 721
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior. Fluoxetine is not approved for use in children younger than 7 years old.
Sotalol can cause life-threatening irregular heartbeats. To lower this risk, you will start or restart sotalol in a hospital where your heart can be monitored. If your QT interval (a measure on your heart tracing) gets too long (500 msec or greater), your doctor may lower your dose or stop the medicine. Your doctor will check your kidney function to decide the right dose for you.
Talk to your doctor if you are pregnant or plan to become pregnant. Fluoxetine should only be used during pregnancy if the benefit outweighs the risk to the baby. Breastfeeding is not recommended while taking fluoxetine.
Sotalol can harm your unborn baby, so talk to your doctor if you are pregnant or plan to become pregnant. Sotalol can pass into breast milk and may harm a nursing infant, so do not breastfeed while taking sotalol.
Also Compare, Nearby Drugs
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How to Read This fluoxetine vs sotalol Comparison
fluoxetine is classified in the Selective Serotonin Reuptake Inhibitor (SSRI) drug class, while sotalol sits within the Class III Antiarrhythmic / Beta-Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluoxetine has 15,944 submissions while sotalol has 4,414. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these medicines can both affect your heart's rhythm. using them together might make heart rhythm problems more likely.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluoxetine or sotalol.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.