Sotalol and Albuterol Interaction
Drug interaction information between Sotalol and Albuterol.
Sotalol and Albuterol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sotalol and Albuterol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Sotalol blocks the effects of albuterol, which can make it harder for the inhaler to help you breathe.
What To Do
You may need to use a higher dose of albuterol to get the same relief while taking sotalol.
FDA Label Information
7.5 Beta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol.
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Diltiazem minor
Albuterol Also Interacts With
- Theophylline major
- Albuterol/Ipratropium moderate
- Atomoxetine moderate
- Digoxin minor
- Glimepiride minor
Frequently Asked Questions
Can I take Sotalol and Albuterol together?
This is a minor interaction. You may need to use a higher dose of albuterol to get the same relief while taking sotalol.
How serious is the interaction between Sotalol and Albuterol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Sotalol and Albuterol interact?
Sotalol blocks the effects of albuterol, which can make it harder for the inhaler to help you breathe.
Understanding the Sotalol and Albuterol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Sotalol belongs to the Class III Antiarrhythmic / Beta-Blocker class and Albuterol belongs to the Short-Acting Beta-2 Agonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Sotalol blocks the effects of albuterol, which can make it harder for the inhaler to help you breathe. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Sotalol has 13 total documented interactions on file in this dataset, and Albuterol has 16. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You may need to use a higher dose of albuterol to get the same relief while taking sotalol. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Sotalol or Albuterol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.