Sotalol and Albuterol Interaction
Drug interaction information between Sotalol and Albuterol.
Sotalol and Albuterol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sotalol and Albuterol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sotalol blocks the effects of albuterol, which can make it harder for the inhaler to help you breathe.
FDA Label Information
7.5 Beta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol.
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Diltiazem minor
Albuterol Also Interacts With
- Theophylline major
- Albuterol/Ipratropium moderate
- Atomoxetine moderate
- Digoxin minor
- Glimepiride minor
Frequently Asked Questions
What SPL severity band is on file for Sotalol + Albuterol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Albuterol has 16 labeled pairs on file vs Sotalol's 13. In the minor band specifically: Sotalol has 9 (also Diltiazem, Verapamil, Clozapine, Fluoxetine); Albuterol has 13 (also Digoxin, Glimepiride, Insulin Aspart, Insulin Degludec).
What mechanism field is on file for Sotalol and Albuterol?
Sotalol blocks the effects of albuterol, which can make it harder for the inhaler to help you breathe.
Albuterol carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is minor · classes on file: Sotalol (Class III Antiarrhythmic / Beta-Blocker); Albuterol (Short-Acting Beta-2 Agonist).
Albuterol has 1 major-labeled pair vs Sotalol's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 9 minor · 13 total
- Other minor peers for Sotalol
- Diltiazem
- Verapamil
- Clozapine
- Fluoxetine
1 major · 2 moderate · 13 minor · 16 total
- Other minor peers for Albuterol
- Digoxin
- Glimepiride
- Insulin Aspart
- Insulin Degludec
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.