Sotalol and Verapamil Interaction
Drug interaction information between Sotalol and Verapamil.
Sotalol and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sotalol and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both work to slow your heart rate and the speed of electrical signals in the heart.
FDA Label Information
7.2 Negative Chronotropes Digitalis glycosides, diltiazem, verapamil, and beta-blockers slow atrioventricular conduction and decrease heart rate.
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Sotalol + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Sotalol's 13. In the minor band specifically: Sotalol has 9 (also Albuterol, Diltiazem, Clozapine, Fluoxetine); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Sotalol and Verapamil?
These drugs both work to slow your heart rate and the speed of electrical signals in the heart.
Verapamil carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is minor · classes on file: Sotalol (Class III Antiarrhythmic / Beta-Blocker); Verapamil (Calcium Channel Blocker).
Verapamil has 4 major-labeled pairs vs Sotalol's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 9 minor · 13 total
- Other minor peers for Sotalol
- Albuterol
- Diltiazem
- Clozapine
- Fluoxetine
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.