What the FDA labels say about taking them together
Fluoxetine and pimozide
Fluoxetine's FDA label of January 8, 2026 names pimozide in its contraindications section, and pimozide's label names fluoxetine too. The fluoxetine label: “Pimozide and thioridazine are contraindicated for use with PROZAC.”
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the pimozide FDA label on DailyMed (effective August 12, 2026, Par Health USA, LLC).
What does the fluoxetine label say about pimozide?
Fluoxetine label, contraindicationsThe use of PROZAC is contraindicated with the following: Pimozide [see Warnings and Precautions ( 5.11 ) and Drug Interactions ( 7.7 , 7.8 )] Thioridazine [see Warnings and Precautions ( 5.11 ) and Drug Interactions ( 7.7 , 7.8 )] Pimozide and thioridazine prolong the QT interval.
Fluoxetine label, drug interactionsPotential for PROZAC to affect Other Drugs Pimozide – Concomitant use in patients taking pimozide is contraindicated.
Fluoxetine label, warnings and precautionsPimozide and thioridazine are contraindicated for use with PROZAC.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the pimozide label say about fluoxetine?
Pimozide label, drug interactionsRare case reports have suggested possible additive effects of pimozide and fluoxetine leading to bradycardia.
Source: FDA drug label (Pimozide), Par Health USA, LLC, effective August 12, 2026 (SPL set 70b079e2-a1f7-4a93-8685-d60a4d7c1280), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Pimozide | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $1.23 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once