What the FDA labels say about taking them together
Aspirin and fluoxetine
Fluoxetine's FDA label of January 8, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name fluoxetine. The fluoxetine label: “Use with NSAIDs, aspirin, warfarin, or other drugs that affect coagulation may potentiate the risk of gastrointestinal or other bleeding Angle-Closure Glaucoma:”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the aspirin label say about fluoxetine?
Aspirin's label (effective September 9, 2025) does not name fluoxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the fluoxetine label say about aspirin?
Fluoxetine label, drug interactionsPotential for elevation of haloperidol and clozapine levels ( 7.7 ) Anticonvulsants: Potential for elevated phenytoin and carbamazepine levels and clinical anticonvulsant toxicity ( 7.7 ) Serotonergic Drugs: ( 2.9 , 2.10 , 4.1 , 5.2 ) Drugs that Interfere with Hemostasis (e.g. NSAIDs, Aspirin, Warfarin):
Fluoxetine label, warnings and precautionsUse with NSAIDs, aspirin, warfarin, or other drugs that affect coagulation may potentiate the risk of gastrointestinal or other bleeding ( 5.7 ) Angle-Closure Glaucoma:
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Fluoxetine | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Depression, Anxiety, Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.0519 per capsule 40 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once