Sotalol and Amiodarone Interaction
Drug interaction information between Sotalol and Amiodarone.
Sotalol and Amiodarone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sotalol and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs affect the electrical timing of your heartbeat in the same way. Taking them together can cause the heart's resting phase to last too long, which increases the risk of life-threatening heart rhythm problems.
FDA Label Information
Class Ia antiarrhythmic drugs, such as disopyramide, quinidine, and procainamide, and other Class III drugs (for example, amiodarone) are not recommended as concomitant therapy with sotalol hydrochloride, because of their potential to prolong refractoriness [see Warnings and Precautions ( 5.2 )].
Sotalol Also Interacts With
- Clonidine moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
- Diltiazem minor
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Sotalol + Amiodarone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Sotalol's 13. In the moderate band specifically: Sotalol has 4 (also Clonidine, Clarithromycin, Digoxin); Amiodarone has 9 (also Lithium, Clarithromycin, Fluconazole, Ledipasvir/Sofosbuvir).
What mechanism field is on file for Sotalol and Amiodarone?
Both drugs affect the electrical timing of your heartbeat in the same way. Taking them together can cause the heart's resting phase to last too long, which increases the risk of life-threatening heart rhythm problems.
Amiodarone carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is moderate · classes on file: Sotalol (Class III Antiarrhythmic / Beta-Blocker); Amiodarone (Class III Antiarrhythmic).
Amiodarone has 4 major-labeled pairs vs Sotalol's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 9 minor · 13 total
- Other moderate peers for Sotalol
- Clonidine
- Clarithromycin
- Digoxin
4 major · 9 moderate · 29 minor · 42 total
- Other moderate peers for Amiodarone
- Lithium
- Clarithromycin
- Fluconazole
- Ledipasvir/Sofosbuvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.