Sotalol and Digoxin Interaction
Drug interaction information between Sotalol and Digoxin.
Sotalol and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sotalol and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together can increase the chance of developing dangerous, irregular heartbeats. This may be due to the drugs themselves or the heart condition being treated.
FDA Label Information
Antiarrthymics Dofetilide Concomitant administration with digoxin was associated with a higher rate of torsades de pointes Sotalol Proarrhythmic events were more common in patients receiving sotalol and digoxin than on either alone; it is not clear whether this represents an interaction or is related to the presence of CHF, a known risk factor for proarrhythmia, in patients receiving digoxin.
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Albuterol minor
- Diltiazem minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Dofetilide moderate
- Ivabradine moderate
- Dopamine moderate
Frequently Asked Questions
What SPL severity band is on file for Sotalol + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Sotalol's 13. In the moderate band specifically: Sotalol has 4 (also Clonidine, Amiodarone, Clarithromycin); Digoxin has 13 (also Dofetilide, Ivabradine, Dopamine, Epinephrine).
What mechanism field is on file for Sotalol and Digoxin?
Using these two drugs together can increase the chance of developing dangerous, irregular heartbeats. This may be due to the drugs themselves or the heart condition being treated.
Digoxin carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is moderate · classes on file: Sotalol (Class III Antiarrhythmic / Beta-Blocker); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Sotalol's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 9 minor · 13 total
- Other moderate peers for Sotalol
- Clonidine
- Amiodarone
- Clarithromycin
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Dofetilide
- Ivabradine
- Dopamine
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.