Sotalol and Clozapine Interaction
Drug interaction information between Sotalol and Clozapine.
Sotalol and Clozapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sotalol and Clozapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can change the electrical rhythm of your heart. Taking them together increases the risk of a serious heart rhythm problem called QT prolongation.
FDA Label Information
Drugs that cause QT prolongation include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, thioridazine, mesoridazine, droperidol, and pimozide), specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin), Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class III antiarrhythmics (e.g., amiodarone, sotalol), and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus) [see Warnings and Precautions (5.9) ] .
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Frequently Asked Questions
What SPL severity band is on file for Sotalol + Clozapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Sotalol's 13. In the minor band specifically: Sotalol has 9 (also Albuterol, Diltiazem, Verapamil, Fluoxetine); Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Duloxetine).
What mechanism field is on file for Sotalol and Clozapine?
Both of these medicines can change the electrical rhythm of your heart. Taking them together increases the risk of a serious heart rhythm problem called QT prolongation.
Clozapine's labeled portfolio outnumbers Sotalol
SPL source-record counts only. This page's band is minor · classes on file: Sotalol (Class III Antiarrhythmic / Beta-Blocker); Clozapine (Atypical Antipsychotic).
0 major · 4 moderate · 9 minor · 13 total
- Other minor peers for Sotalol
- Albuterol
- Diltiazem
- Verapamil
- Fluoxetine
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Duloxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.