Sotalol and Diltiazem Interaction
Drug interaction information between Sotalol and Diltiazem.
Sotalol and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sotalol and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines slow down your heart rate and the electrical signals that travel through your heart.
FDA Label Information
7.2 Negative Chronotropes Digitalis glycosides, diltiazem, verapamil, and beta-blockers slow atrioventricular conduction and decrease heart rate.
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Sotalol + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Sotalol's 13. In the minor band specifically: Sotalol has 9 (also Albuterol, Verapamil, Clozapine, Fluoxetine); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Sotalol and Diltiazem?
Both of these medicines slow down your heart rate and the electrical signals that travel through your heart.
Diltiazem carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is minor · classes on file: Sotalol (Class III Antiarrhythmic / Beta-Blocker); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Sotalol's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 9 minor · 13 total
- Other minor peers for Sotalol
- Albuterol
- Verapamil
- Clozapine
- Fluoxetine
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.