Sotalol and Clonidine Interaction
Drug interaction information between Sotalol and Clonidine.
Sotalol and Clonidine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sotalol and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines slow down your heart rate, which can cause your heart to beat too slowly. Additionally, taking them together can cause a dangerous spike in blood pressure if the clonidine is stopped suddenly.
FDA Label Information
7.6 Clonidine Concomitant use with sotalol increases the risk of bradycardia and AV block. Because beta-blockers may potentiate the rebound hypertension sometimes observed after clonidine discontinuation, withdraw sotalol several days before the gradual withdrawal of clonidine to reduce the risk of rebound hypertension.
Sotalol Also Interacts With
- Amiodarone moderate
- Clarithromycin moderate
- Digoxin moderate
- Albuterol minor
- Diltiazem minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Amitriptyline minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Sotalol + Clonidine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Sotalol's 13. In the moderate band specifically: Sotalol has 4 (also Amiodarone, Clarithromycin, Digoxin); Clonidine has 4 (also Carvedilol, Metoprolol, Repaglinide).
What mechanism field is on file for Sotalol and Clonidine?
Both of these medicines slow down your heart rate, which can cause your heart to beat too slowly. Additionally, taking them together can cause a dangerous spike in blood pressure if the clonidine is stopped suddenly.
Clonidine's labeled portfolio outnumbers Sotalol
SPL source-record counts only. This page's band is moderate · classes on file: Sotalol (Class III Antiarrhythmic / Beta-Blocker); Clonidine (Central Alpha-2 Agonist).
0 major · 4 moderate · 9 minor · 13 total
- Other moderate peers for Sotalol
- Amiodarone
- Clarithromycin
- Digoxin
0 major · 4 moderate · 25 minor · 29 total
- Other moderate peers for Clonidine
- Carvedilol
- Metoprolol
- Repaglinide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.