What the FDA labels say about taking them together
Clonidine and sotalol
Sotalol's FDA label of December 16, 2024 names clonidine in its drug interactions section; the clonidine labels PlainMeds reads (4) do not name sotalol. The sotalol label: “Because beta-blockers may potentiate the rebound hypertension sometime observed after clonidine discontinuation, withdraw sotalol several days before the gradual withdrawal of clonidine to reduce the risk of rebound …”
Check it at the source: the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.); the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.).
What does the clonidine label say about sotalol?
Clonidine's label (effective March 30, 2026) and its 3 other brand-application labels do not name sotalol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
What does the sotalol label say about clonidine?
Sotalol label, drug interactionsBecause beta-blockers may potentiate the rebound hypertension sometimes observed after clonidine discontinuation, withdraw sotalol several days before the gradual withdrawal of clonidine to reduce the risk of rebound hypertension.
Source: FDA drug label (Sotalol Hydrochloride, NDA022306), ALTATHERA Pharmaceuticals, LLC, effective July 31, 2025 (SPL set ff3061ab-d930-4318-a5be-684e38be229e), via openFDA
Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonidine | Sotalol | |
|---|---|---|
| Labeled for | High blood pressure, ADHD, Pain | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0241 per tablet 0.1 mg tablet | $0.0707 per tablet 80 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once