Fluoxetine and Erythromycin Interaction
Drug interaction information between Fluoxetine and Erythromycin.
Fluoxetine and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluoxetine and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines can both affect the electrical timing of your heartbeat. This can lead to a higher risk of heart rhythm issues.
FDA Label Information
These include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Fluoxetine + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Erythromycin's 63. In the minor band specifically: Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Imipramine); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Fluoxetine and Erythromycin?
These two medicines can both affect the electrical timing of your heartbeat. This can lead to a higher risk of heart rhythm issues.
Fluoxetine carries more major-labeled pairs than Erythromycin
SPL source-record counts only. This page's band is minor · classes on file: Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Erythromycin (Macrolide Antibiotic).
Fluoxetine has 6 major-labeled pairs vs Erythromycin's 4. This page itself is in the minor band, not the major band.
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Imipramine
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.