Fluoxetine and Moxifloxacin Interaction
Drug interaction information between Fluoxetine and Moxifloxacin.
Fluoxetine and Moxifloxacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluoxetine and Moxifloxacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can change the way your heart beats. Using them together may increase the risk of developing a dangerous heart rhythm.
FDA Label Information
These include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Moxifloxacin Also Interacts With
- Lefamulin moderate
- Warfarin minor
- Sotalol minor
- Sucralfate minor
- Zinc Sulfate minor
Frequently Asked Questions
What SPL severity band is on file for Fluoxetine + Moxifloxacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Moxifloxacin's 10. In the minor band specifically: Fluoxetine has 43 (also Ketoconazole, Lithium, Erythromycin, Imipramine); Moxifloxacin has 9 (also Warfarin, Sotalol, Sucralfate, Zinc Sulfate).
What mechanism field is on file for Fluoxetine and Moxifloxacin?
Both of these drugs can change the way your heart beats. Using them together may increase the risk of developing a dangerous heart rhythm.
Fluoxetine carries more major-labeled pairs than Moxifloxacin
SPL source-record counts only. This page's band is minor · classes on file: Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Moxifloxacin (Fluoroquinolone Antibiotic).
Fluoxetine has 6 major-labeled pairs vs Moxifloxacin's 0. This page itself is in the minor band, not the major band.
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Erythromycin
- Imipramine
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Moxifloxacin
- Warfarin
- Sotalol
- Sucralfate
- Zinc Sulfate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.