What the FDA labels say about taking them together
Clozapine and cyclobenzaprine
Clozapine's FDA label of June 6, 2025 names cyclobenzaprine in its drug interactions section; the cyclobenzaprine labels PlainMeds reads (3) do not name clozapine. The clozapine label: “Anticholinergic Drugs Concomitant treatment with clozapine and other drugs with anticholinergic activity can increase the risk for anticholinergic toxicity and severe gastrointestinal adverse reactions related to …”
Check it at the source: the clozapine FDA label on DailyMed (effective June 6, 2025, HLS Therapeutics (USA), Inc.); the cyclobenzaprine FDA label on DailyMed (effective February 21, 2025, Jubilant Cadista Pharmaceuticals Inc.).
What does the clozapine label say about cyclobenzaprine?
Clozapine label, drug interactionsAnticholinergic Drugs Concomitant treatment with clozapine and other drugs with anticholinergic activity (e.g., benztropine, cyclobenzaprine, diphenhydramine) can increase the risk for anticholinergic toxicity and severe gastrointestinal adverse reactions related to hypomotility.
Source: FDA drug label (Clozaril), NDA019758 (Heritage Life), as published by HLS Therapeutics (USA), Inc., effective June 6, 2025 (SPL set 90876802-0e3a-44c9-9ff7-1754dfbe736a), via openFDA; the full label on DailyMed
What does the cyclobenzaprine label say about clozapine?
Cyclobenzaprine's label (effective February 21, 2025) and its 2 other brand-application labels do not name clozapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cyclobenzaprine Hydrochloride), Jubilant Cadista Pharmaceuticals Inc., effective February 21, 2025 (SPL set 592871f6-0eb2-4624-9e10-bd8bf767c002), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clozapine | Cyclobenzaprine | |
|---|---|---|
| Labeled for | Schizophrenia | Muscle spasms and spasticity, Nerve pain and fibromyalgia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.610 per tablet 100 mg tablet | $0.0171 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once