Clozapine and Cyclobenzaprine Interaction
Drug interaction information between Clozapine and Cyclobenzaprine.
Clozapine and Cyclobenzaprine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Clozapine and Cyclobenzaprine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs have similar side effects that can slow down your digestive system and cause confusion or dry mouth. Combining them makes these side effects much more likely and can lead to severe constipation or toxicity.
FDA Label Information
Anticholinergic Drugs Concomitant treatment with clozapine and other drugs with anticholinergic activity (e.g., benztropine, cyclobenzaprine, diphenhydramine) can increase the risk for anticholinergic toxicity and severe gastrointestinal adverse reactions related to hypomotility.
Clozapine Also Interacts With
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
- Bupropion minor
Cyclobenzaprine Also Interacts With
- Tapentadol moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine minor
- Buprenorphine/Naloxone minor
Frequently Asked Questions
What SPL severity band is on file for Clozapine + Cyclobenzaprine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Cyclobenzaprine's 17. In the moderate band specifically: Clozapine has 3 (also Diphenhydramine, Fluoxetine); Cyclobenzaprine has 3 (also Tapentadol, Tranylcypromine).
What mechanism field is on file for Clozapine and Cyclobenzaprine?
Both drugs have similar side effects that can slow down your digestive system and cause confusion or dry mouth. Combining them makes these side effects much more likely and can lead to severe constipation or toxicity.
Clozapine's labeled portfolio outnumbers Cyclobenzaprine
SPL source-record counts only. This page's band is moderate · classes on file: Clozapine (Atypical Antipsychotic); Cyclobenzaprine (Muscle Relaxant).
0 major · 3 moderate · 39 minor · 42 total
- Other moderate peers for Clozapine
- Diphenhydramine
- Fluoxetine
0 major · 3 moderate · 14 minor · 17 total
- Other moderate peers for Cyclobenzaprine
- Tapentadol
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.