Clozapine and Escitalopram Interaction
Drug interaction information between Clozapine and Escitalopram.
Clozapine and Escitalopram have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clozapine and Escitalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Escitalopram slows down the process of clearing clozapine from your body. This leads to higher amounts of clozapine in your system than intended.
FDA Label Information
CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with VERSACLOZ and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3) ] .
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Bupropion minor
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Aspirin moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Clozapine + Escitalopram?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Escitalopram's 12. In the minor band specifically: Clozapine has 39 (also Sertraline, Bupropion, Duloxetine, Paroxetine); Escitalopram has 7 (also Buspirone, Sumatriptan, Carbamazepine, Lithium).
What mechanism field is on file for Clozapine and Escitalopram?
Escitalopram slows down the process of clearing clozapine from your body. This leads to higher amounts of clozapine in your system than intended.
Escitalopram carries more major-labeled pairs than Clozapine
SPL source-record counts only. This page's band is minor · classes on file: Clozapine (Atypical Antipsychotic); Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
Escitalopram has 3 major-labeled pairs vs Clozapine's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Bupropion
- Duloxetine
- Paroxetine
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Escitalopram
- Buspirone
- Sumatriptan
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.