Bupropion · more major-labeled pairs than Clozapine
SPL labels Clozapine + Bupropion as minor; Clozapine 39 / Bupropion 32 in that band.
Mechanism on file: Bupropion blocks the proteins in your body that break down clozapine, which can cause clozapine to build up in your blood.
FDA SPL severity: Minor
Clozapine + Bupropion · SPL mechanism field
Bupropion blocks the proteins in your body that break down clozapine, which can cause clozapine to build up in your blood.
Minor band excerpt · Clozapine with Bupropion
CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with VERSACLOZ and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3) ] .
Clozapine · 42 SPL pairs (broader portfolio than Bupropion)
- Amiodarone minor
- Carbamazepine minor
- Chlorpromazine minor
- Cimetidine minor
Bupropion · 1 major-labeled pairs (vs Clozapine's 0)
- Brexpiprazole minor
- Carbamazepine minor
- Clopidogrel minor
- Codeine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.