Clozapine and Duloxetine Interaction
Drug interaction information between Clozapine and Duloxetine.
Clozapine and Duloxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clozapine and Duloxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Duloxetine slows down the process your body uses to get rid of clozapine, which can lead to higher drug levels and more side effects.
FDA Label Information
CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with VERSACLOZ and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3) ] .
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Sertraline minor
- Escitalopram minor
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Clozapine + Duloxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Duloxetine's 18. In the minor band specifically: Clozapine has 39 (also Sertraline, Escitalopram, Bupropion, Paroxetine); Duloxetine has 17 (also Fluoxetine, Famotidine, Buspirone, Paroxetine).
What mechanism field is on file for Clozapine and Duloxetine?
Duloxetine slows down the process your body uses to get rid of clozapine, which can lead to higher drug levels and more side effects.
Clozapine's labeled portfolio outnumbers Duloxetine
SPL source-record counts only. This page's band is minor · classes on file: Clozapine (Atypical Antipsychotic); Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Sertraline
- Escitalopram
- Bupropion
- Paroxetine
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Buspirone
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.