Clozapine and Sertraline Interaction
Drug interaction information between Clozapine and Sertraline.
Clozapine and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clozapine and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sertraline interferes with the way your body gets rid of clozapine. This can cause clozapine to reach high levels in your blood and increase the risk of side effects.
FDA Label Information
CYP2D6 and CYP3A4 Inhibitors Concomitant treatment with VERSACLOZ and CYP2D6 or CYP3A4 inhibitors (e.g., cimetidine, escitalopram, erythromycin, paroxetine, bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see Clinical Pharmacology (12.3) ] .
Clozapine Also Interacts With
- Cyclobenzaprine moderate
- Diphenhydramine moderate
- Fluoxetine moderate
- Escitalopram minor
- Bupropion minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Clozapine + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clozapine has 42 labeled pairs on file vs Sertraline's 34. In the minor band specifically: Clozapine has 39 (also Escitalopram, Bupropion, Duloxetine, Paroxetine); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Clozapine and Sertraline?
Sertraline interferes with the way your body gets rid of clozapine. This can cause clozapine to reach high levels in your blood and increase the risk of side effects.
Sertraline carries more major-labeled pairs than Clozapine
SPL source-record counts only. This page's band is minor · classes on file: Clozapine (Atypical Antipsychotic); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Sertraline has 1 major-labeled pair vs Clozapine's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 39 minor · 42 total
- Other minor peers for Clozapine
- Escitalopram
- Bupropion
- Duloxetine
- Paroxetine
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.