Salmeterol and Itraconazole Interaction
Drug interaction information between Salmeterol and Itraconazole.
Salmeterol and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Salmeterol and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole makes it harder for your body to get rid of salmeterol. This can cause the medicine to build up and potentially cause heart problems.
FDA Label Information
Concomitant drug dose reduction may be necessary Respiratory Drugs Salmeterol Not recommended during and 2 weeks after itraconazole treatment.
Salmeterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone minor
- Darunavir minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Salmeterol + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Salmeterol's 7. In the moderate band specifically: Salmeterol has 4 (also Ketoconazole, Clarithromycin, Nirmatrelvir/Ritonavir); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Salmeterol and Itraconazole?
Itraconazole makes it harder for your body to get rid of salmeterol. This can cause the medicine to build up and potentially cause heart problems.
Itraconazole carries more major-labeled pairs than Salmeterol
SPL source-record counts only. This page's band is moderate · classes on file: Salmeterol (Long-Acting Beta-2 Agonist (LABA)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Salmeterol's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Salmeterol
- Ketoconazole
- Clarithromycin
- Nirmatrelvir/Ritonavir
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.