Salmeterol and Ketoconazole Interaction
Drug interaction information between Salmeterol and Ketoconazole.
Salmeterol and Ketoconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Salmeterol and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole stops your body from breaking down salmeterol, which can cause the drug to build up in your blood. This increase can lead to heart issues and other side effects throughout your body.
FDA Label Information
Avoid strong cytochrome P450 3A4 inhibitors (e.g., ritonavir, ketoconazole): May increase risk of systemic corticosteroid and cardiovascular effects. The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with Fluticasone Propionate/Salmeterol MDPI is not recommended because increased systemic corticosteroid and increased cardiovascular adverse effects may occur. Ketoconazole : Fluticasone Propionate: Coadministration of orally inhaled fluticasone propionate (1,000 mcg) and...
Salmeterol Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone minor
- Darunavir minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Salmeterol + Ketoconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Salmeterol's 7. In the moderate band specifically: Salmeterol has 4 (also Clarithromycin, Itraconazole, Nirmatrelvir/Ritonavir); Ketoconazole has 22 (also Alprazolam, Aprepitant, Budesonide/Formoterol, Dexamethasone).
What mechanism field is on file for Salmeterol and Ketoconazole?
Ketoconazole stops your body from breaking down salmeterol, which can cause the drug to build up in your blood. This increase can lead to heart issues and other side effects throughout your body.
Ketoconazole carries more major-labeled pairs than Salmeterol
SPL source-record counts only. This page's band is moderate · classes on file: Salmeterol (Long-Acting Beta-2 Agonist (LABA)); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Salmeterol's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Salmeterol
- Clarithromycin
- Itraconazole
- Nirmatrelvir/Ritonavir
6 major · 22 moderate · 85 minor · 113 total
- Other moderate peers for Ketoconazole
- Alprazolam
- Aprepitant
- Budesonide/Formoterol
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.