Salmeterol and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Salmeterol and Nirmatrelvir/Ritonavir.
Salmeterol and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Salmeterol and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination makes salmeterol stay in your body longer, which can cause dangerous heart rhythms or a racing heart.
FDA Label Information
Long-acting beta-adrenoceptor agonist salmeterol ↑ salmeterol Avoid concomitant use with PAXLOVID. The combination may result in increased risk of cardiovascular adverse events associated with salmeterol, including QT prolongation, palpitations, and sinus tachycardia.
Salmeterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Fluticasone minor
- Darunavir minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Salmeterol + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Salmeterol's 7. In the moderate band specifically: Salmeterol has 4 (also Ketoconazole, Clarithromycin, Itraconazole); Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Salmeterol and Nirmatrelvir/Ritonavir?
This combination makes salmeterol stay in your body longer, which can cause dangerous heart rhythms or a racing heart.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Salmeterol
SPL source-record counts only. This page's band is moderate · classes on file: Salmeterol (Long-Acting Beta-2 Agonist (LABA)); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Salmeterol's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Salmeterol
- Ketoconazole
- Clarithromycin
- Itraconazole
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.