Salmeterol and Fluticasone Interaction
Drug interaction information between Salmeterol and Fluticasone.
Salmeterol and Fluticasone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Salmeterol and Fluticasone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs are broken down by the same liver enzyme and are often used together safely in a single inhaler to treat breathing problems.
FDA Label Information
7 DRUG INTERACTIONS Fluticasone Propionate/Salmeterol MDPI has been used concomitantly with other drugs, including short‑acting beta 2 ‑agonists, and intranasal corticosteroids, commonly used in patients with asthma without adverse drug reactions [see Clinical Pharmacology ( 12.2 )] . No formal drug interaction trials have been performed with Fluticasone Propionate/Salmeterol MDPI. ( 7.4 ) 7.1 Inhibitors of Cytochrome P450 3A4 Fluticasone propionate and salmeterol, the individual components of this product, are substrates of CYP3A4.
Salmeterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Darunavir minor
Fluticasone Also Interacts With
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone/Salmeterol minor
- Fluticasone/Umeclidinium/Vilanterol minor
- Fluticasone/Vilanterol minor
Frequently Asked Questions
What SPL severity band is on file for Salmeterol + Fluticasone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Salmeterol and Fluticasone tie at 7 labeled pairs each. minor-band counts: Salmeterol 3 alongside Darunavir, Fluticasone/Salmeterol; Fluticasone 5 alongside Fluticasone/Salmeterol, Fluticasone, Fluticasone/Vilanterol, Itraconazole.
What mechanism field is on file for Salmeterol and Fluticasone?
Both drugs are broken down by the same liver enzyme and are often used together safely in a single inhaler to treat breathing problems.
Salmeterol and Fluticasone · minor-band peers
SPL source-record counts only. This page's band is minor · classes on file: Salmeterol (Long-Acting Beta-2 Agonist (LABA)); Fluticasone (Corticosteroid).
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Salmeterol
- Darunavir
- Fluticasone/Salmeterol
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Fluticasone
- Fluticasone/Salmeterol
- Fluticasone
- Fluticasone/Vilanterol
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.