Salmeterol and Darunavir Interaction
Drug interaction information between Salmeterol and Darunavir.
Salmeterol and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Salmeterol and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir can cause the levels of salmeterol to increase in your body by slowing down how the drug is removed.
FDA Label Information
irinotecan ↑ salmeterol Discontinue darunavir/ritonavir at least 1 week prior to starting irinotecan therapy.
Salmeterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Salmeterol + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Salmeterol's 7. In the minor band specifically: Salmeterol has 3 (also Fluticasone, Fluticasone/Salmeterol); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Salmeterol and Darunavir?
Darunavir can cause the levels of salmeterol to increase in your body by slowing down how the drug is removed.
Darunavir carries more major-labeled pairs than Salmeterol
SPL source-record counts only. This page's band is minor · classes on file: Salmeterol (Long-Acting Beta-2 Agonist (LABA)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Salmeterol's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Salmeterol
- Fluticasone
- Fluticasone/Salmeterol
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.