Gemfibrozil and Ezetimibe/Simvastatin Interaction
Drug interaction information between Gemfibrozil and Ezetimibe/Simvastatin.
Gemfibrozil and Ezetimibe/Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Gemfibrozil and Ezetimibe/Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can cause muscle problems on their own, and using them together significantly increases the risk of severe muscle breakdown.
FDA Label Information
Cyclosporine, Danazol, or Gemfibrozil Clinical Impact: The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine, danazol, or gemfibrozil with VYTORIN. Gemfibrozil may cause myopathy when given alone. Intervention: Concomitant use of cyclosporine, danazol, or gemfibrozil with VYTORIN is contraindicated [see Contraindications (4) ] .
Gemfibrozil Also Interacts With
- Ezetimibe major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
- Eluxadoline moderate
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Frequently Asked Questions
What SPL severity band is on file for Gemfibrozil + Ezetimibe/Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe/Simvastatin has 23 labeled pairs on file vs Gemfibrozil's 20. In the major band specifically: Gemfibrozil has 4 (also Ezetimibe, Repaglinide, Simvastatin); Ezetimibe/Simvastatin has 8 (also Amlodipine, Diltiazem, Verapamil, Cyclosporine).
What mechanism field is on file for Gemfibrozil and Ezetimibe/Simvastatin?
Both of these medications can cause muscle problems on their own, and using them together significantly increases the risk of severe muscle breakdown.
Ezetimibe/Simvastatin carries more major-labeled pairs than Gemfibrozil
SPL source-record counts only. This page's band is major · classes on file: Gemfibrozil (Fibrate); Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Gemfibrozil's 4.
4 major · 8 moderate · 8 minor · 20 total
- Other major peers for Gemfibrozil
- Ezetimibe
- Repaglinide
- Simvastatin
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Amlodipine
- Diltiazem
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.