Gemfibrozil and Fluvastatin Interaction
Drug interaction information between Gemfibrozil and Fluvastatin.
Gemfibrozil and Fluvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Gemfibrozil and Fluvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two cholesterol medicines together can cause a dangerous breakdown of muscle tissue.
FDA Label Information
7.3 Gemfibrozil Due to an increased risk of myopathy/rhabdomyolysis when HMG-CoA reductase inhibitors are coadministered with gemfibrozil, concomitant administration of fluvastatin sodium with gemfibrozil should be avoided.
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Fluvastatin Also Interacts With
- Clarithromycin major
- Cyclosporine moderate
- Glyburide moderate
- Niacin moderate
- Phenytoin moderate
Frequently Asked Questions
What SPL severity band is on file for Gemfibrozil + Fluvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Fluvastatin's 12. In the moderate band specifically: Gemfibrozil has 8 (also Atorvastatin, Eluxadoline, Lovastatin, Pitavastatin); Fluvastatin has 6 (also Cyclosporine, Glyburide, Niacin, Phenytoin).
What mechanism field is on file for Gemfibrozil and Fluvastatin?
Taking these two cholesterol medicines together can cause a dangerous breakdown of muscle tissue.
Gemfibrozil carries more major-labeled pairs than Fluvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Gemfibrozil (Fibrate); Fluvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Gemfibrozil has 4 major-labeled pairs vs Fluvastatin's 1. This page itself is in the moderate band, not the major band.
4 major · 8 moderate · 8 minor · 20 total
- Other moderate peers for Gemfibrozil
- Atorvastatin
- Eluxadoline
- Lovastatin
- Pitavastatin
1 major · 6 moderate · 5 minor · 12 total
- Other moderate peers for Fluvastatin
- Cyclosporine
- Glyburide
- Niacin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.