Gemfibrozil and Eluxadoline Interaction
Drug interaction information between Gemfibrozil and Eluxadoline.
Gemfibrozil and Eluxadoline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Gemfibrozil and Eluxadoline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause constipation as a side effect, making it much more likely to happen if they are taken at the same time.
FDA Label Information
Examples: cyclosporine, gemfibrozil, antiretrovirals (atazanavir, lopinavir, ritonavir, saquinavir, tipranavir), rifampin, eltrombopag Drugs that Cause Constipation Clinical Impact: Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions Intervention: Avoid use with other drugs that may cause constipation (see below); loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use.
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Eluxadoline Also Interacts With
- Rosuvastatin moderate
- Rifampin moderate
- Loperamide moderate
- Cyclosporine minor
- Alosetron minor
Frequently Asked Questions
What SPL severity band is on file for Gemfibrozil + Eluxadoline?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Eluxadoline's 6. In the moderate band specifically: Gemfibrozil has 8 (also Atorvastatin, Fluvastatin, Lovastatin, Pitavastatin); Eluxadoline has 4 (also Rosuvastatin, Rifampin, Loperamide).
What mechanism field is on file for Gemfibrozil and Eluxadoline?
Both drugs can cause constipation as a side effect, making it much more likely to happen if they are taken at the same time.
Gemfibrozil carries more major-labeled pairs than Eluxadoline
SPL source-record counts only. This page's band is moderate · classes on file: Gemfibrozil (Fibrate); Eluxadoline (Mu-Opioid Receptor Agonist (IBS-D)).
Gemfibrozil has 4 major-labeled pairs vs Eluxadoline's 0. This page itself is in the moderate band, not the major band.
4 major · 8 moderate · 8 minor · 20 total
- Other moderate peers for Gemfibrozil
- Atorvastatin
- Fluvastatin
- Lovastatin
- Pitavastatin
0 major · 4 moderate · 2 minor · 6 total
- Other moderate peers for Eluxadoline
- Rosuvastatin
- Rifampin
- Loperamide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.