Gemfibrozil and Eluxadoline Interaction
Drug interaction information between Gemfibrozil and Eluxadoline.
Gemfibrozil and Eluxadoline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Gemfibrozil and Eluxadoline. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs can cause constipation as a side effect, making it much more likely to happen if they are taken at the same time.
What To Do
Avoid using these medications together to reduce the risk of serious bowel issues.
FDA Label Information
Examples: cyclosporine, gemfibrozil, antiretrovirals (atazanavir, lopinavir, ritonavir, saquinavir, tipranavir), rifampin, eltrombopag Drugs that Cause Constipation Clinical Impact: Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions Intervention: Avoid use with other drugs that may cause constipation (see below); loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use.
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Eluxadoline Also Interacts With
- Rosuvastatin moderate
- Rifampin moderate
- Loperamide moderate
- Cyclosporine minor
- Alosetron minor
Frequently Asked Questions
Can I take Gemfibrozil and Eluxadoline together?
This is a moderate interaction. Avoid using these medications together to reduce the risk of serious bowel issues.
How serious is the interaction between Gemfibrozil and Eluxadoline?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Gemfibrozil and Eluxadoline interact?
Both drugs can cause constipation as a side effect, making it much more likely to happen if they are taken at the same time.
Understanding the Gemfibrozil and Eluxadoline Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Gemfibrozil belongs to the Fibrate class and Eluxadoline belongs to the Mu-Opioid Receptor Agonist (IBS-D) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs can cause constipation as a side effect, making it much more likely to happen if they are taken at the same time. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Gemfibrozil has 20 total documented interactions on file in this dataset, and Eluxadoline has 6. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid using these medications together to reduce the risk of serious bowel issues. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Gemfibrozil or Eluxadoline based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.