Gemfibrozil and Simvastatin Interaction
Drug interaction information between Gemfibrozil and Simvastatin.
Gemfibrozil and Simvastatin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Gemfibrozil and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause muscle damage on their own, and taking them together greatly increases the risk of severe muscle breakdown.
FDA Label Information
Cyclosporine, Danazol, or Gemfibrozil Clinical Impact: The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine, danazol, or gemfibrozil with ezetimibe and simvastatin. Gemfibrozil may cause myopathy when given alone. Intervention: Concomitant use of cyclosporine, danazol, or gemfibrozil with ezetimibe and simvastatin is contraindicated [see Contraindications ( 4 )].
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Atorvastatin moderate
- Eluxadoline moderate
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Gemfibrozil + Simvastatin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Gemfibrozil's 20. In the major band specifically: Gemfibrozil has 4 (also Ezetimibe, Ezetimibe/Simvastatin, Repaglinide); Simvastatin has 11 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone).
What mechanism field is on file for Gemfibrozil and Simvastatin?
Both drugs can cause muscle damage on their own, and taking them together greatly increases the risk of severe muscle breakdown.
Simvastatin carries more major-labeled pairs than Gemfibrozil
SPL source-record counts only. This page's band is major · classes on file: Gemfibrozil (Fibrate); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Gemfibrozil's 4.
4 major · 8 moderate · 8 minor · 20 total
- Other major peers for Gemfibrozil
- Ezetimibe
- Ezetimibe/Simvastatin
- Repaglinide
11 major · 9 moderate · 21 minor · 41 total
- Other major peers for Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.