Ramelteon and Itraconazole Interaction
Drug interaction information between Ramelteon and Itraconazole.
Ramelteon and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ramelteon and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole interferes with the way your body processes ramelteon. This can lead to higher amounts of the medicine in your bloodstream.
FDA Label Information
Antipsychotics, Anxiolytics and Hypnotics Alprazolam a Midazolam (IV) a Aripiprazole a Quetiapine Buspirone a Cariprazine Ramelteon Diazepam a Risperidone a Haloperidol a Suvorexant Monitor for adverse reactions.
Ramelteon Also Interacts With
- Ketoconazole moderate
- Fluconazole moderate
- Donepezil minor
- Doxepin minor
- Rifampin minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Ramelteon + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Ramelteon's 7. In the minor band specifically: Ramelteon has 5 (also Donepezil, Doxepin, Rifampin, Fluvoxamine); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Ramelteon and Itraconazole?
Itraconazole interferes with the way your body processes ramelteon. This can lead to higher amounts of the medicine in your bloodstream.
Itraconazole carries more major-labeled pairs than Ramelteon
SPL source-record counts only. This page's band is minor · classes on file: Ramelteon (Melatonin Receptor Agonist); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Ramelteon's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Ramelteon
- Donepezil
- Doxepin
- Rifampin
- Fluvoxamine
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.