Ramelteon and Fluvoxamine Interaction
Drug interaction information between Ramelteon and Fluvoxamine.
Ramelteon and Fluvoxamine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ramelteon and Fluvoxamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine stops the body from breaking down ramelteon, which can lead to dangerously high levels of the sleep medicine in your system.
FDA Label Information
Ramelteon: See CONTRAINDICATIONS ( 4 ) and WARNINGS AND PRECAUTIONS ( 5.8 ).
Ramelteon Also Interacts With
- Ketoconazole moderate
- Fluconazole moderate
- Donepezil minor
- Doxepin minor
- Rifampin minor
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Metoprolol minor
Frequently Asked Questions
What SPL severity band is on file for Ramelteon + Fluvoxamine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Ramelteon's 7. In the minor band specifically: Ramelteon has 5 (also Donepezil, Doxepin, Rifampin, Itraconazole); Fluvoxamine has 36 (also Metoprolol, Omeprazole, Fluoxetine, Aspirin).
What mechanism field is on file for Ramelteon and Fluvoxamine?
Fluvoxamine stops the body from breaking down ramelteon, which can lead to dangerously high levels of the sleep medicine in your system.
Fluvoxamine carries more major-labeled pairs than Ramelteon
SPL source-record counts only. This page's band is minor · classes on file: Ramelteon (Melatonin Receptor Agonist); Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluvoxamine has 1 major-labeled pair vs Ramelteon's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Ramelteon
- Donepezil
- Doxepin
- Rifampin
- Itraconazole
1 major · 3 moderate · 36 minor · 40 total
- Other minor peers for Fluvoxamine
- Metoprolol
- Omeprazole
- Fluoxetine
- Aspirin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.