What the FDA labels say about taking them together
Ramelteon and rifampin
Ramelteon's FDA label of April 15, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name ramelteon. The ramelteon label: “DRUG INTERACTIONS Rifampin: Decreases exposure to and effects of ramelteon. Ketoconazole (strong CYP3A4 inhibitor):”
Check it at the source: the ramelteon FDA label on DailyMed (effective April 15, 2026, Takeda Pharmaceuticals America, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the ramelteon label say about rifampin?
Ramelteon label, drug interactionsDRUG INTERACTIONS Rifampin (strong CYP enzyme inducer): Decreases exposure to and effects of ramelteon. ( 7.1 ) Ketoconazole (strong CYP3A4 inhibitor):
Source: FDA drug label (Rozerem), Takeda Pharmaceuticals America, Inc., effective April 15, 2026 (SPL set 9de82310-70e8-47b9-b1fc-6c6848b99455), via openFDA; the full label on DailyMed
What does the rifampin label say about ramelteon?
Rifampin's label (effective February 11, 2026) does not name ramelteon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ramelteon | Rifampin | |
|---|---|---|
| Labeled for | Insomnia | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.660 per tablet 8 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once