Ramelteon and Rifampin Interaction
Drug interaction information between Ramelteon and Rifampin.
Ramelteon and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ramelteon and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to break down ramelteon much faster than normal, which lowers the amount of medicine in your system.
FDA Label Information
7 DRUG INTERACTIONS Rifampin (strong CYP enzyme inducer): Decreases exposure to and effects of ramelteon. Rifampin (strong CYP enzyme inducer) Administration of multiple doses of rifampin resulted in a mean decrease of approximately 80% in total exposure to ramelteon and metabolite M-II. Efficacy may be reduced when ramelteon is used in combination with strong CYP enzyme inducers such as rifampin [see Clinical Pharmacology (12.5) ] .
Ramelteon Also Interacts With
- Ketoconazole moderate
- Fluconazole moderate
- Donepezil minor
- Doxepin minor
- Fluvoxamine minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Ramelteon + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Ramelteon's 7. In the minor band specifically: Ramelteon has 5 (also Donepezil, Doxepin, Fluvoxamine, Itraconazole); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Ramelteon and Rifampin?
Rifampin causes your body to break down ramelteon much faster than normal, which lowers the amount of medicine in your system.
Rifampin carries more major-labeled pairs than Ramelteon
SPL source-record counts only. This page's band is minor · classes on file: Ramelteon (Melatonin Receptor Agonist); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Ramelteon's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Ramelteon
- Donepezil
- Doxepin
- Fluvoxamine
- Itraconazole
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.