What the FDA labels say about taking them together
Donepezil and ramelteon
Ramelteon's FDA label of April 15, 2026 names donepezil in its drug interactions section; the donepezil label PlainMeds reads does not name ramelteon. The ramelteon label: “Increases systemic exposure of ramelteon; administer with caution. Donepezil: Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with donepezil.”
Check it at the source: the donepezil FDA label on DailyMed (effective December 30, 2021, Eisai Inc.); the ramelteon FDA label on DailyMed (effective April 15, 2026, Takeda Pharmaceuticals America, Inc.).
What does the donepezil label say about ramelteon?
Donepezil's label (effective December 30, 2021) does not name ramelteon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Aricept), Eisai Inc., effective December 30, 2021 (SPL set 98e451e1-e4d7-4439-a675-c5457ba20975), via openFDA; the full label on DailyMed
What does the ramelteon label say about donepezil?
Ramelteon label, drug interactionsIncreases systemic exposure of ramelteon; administer with caution. ( 7.1 ) Donepezil: Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with donepezil.
Source: FDA drug label (Rozerem), Takeda Pharmaceuticals America, Inc., effective April 15, 2026 (SPL set 9de82310-70e8-47b9-b1fc-6c6848b99455), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Donepezil | Ramelteon | |
|---|---|---|
| Labeled for | Alzheimer's disease | Insomnia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0484 per tablet 10 mg tablet | $0.660 per tablet 8 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once