What the FDA labels say about taking them together
Doxepin and ramelteon
Ramelteon's FDA label of April 15, 2026 names doxepin in its drug interactions section; the doxepin labels PlainMeds reads (3) do not name ramelteon. The ramelteon label: “Increases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with doxepin.”
Check it at the source: the doxepin FDA label on DailyMed (effective December 30, 2025, Leading Pharma, LLC); the ramelteon FDA label on DailyMed (effective April 15, 2026, Takeda Pharmaceuticals America, Inc.).
What does the doxepin label say about ramelteon?
Doxepin's label (effective December 30, 2025) and its 2 other brand-application labels do not name ramelteon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DOXEPIN HYDROCHLORIDE), Leading Pharma, LLC, effective December 30, 2025 (SPL set e6a4cb10-1928-4abe-8797-404c9ddc37dd), via openFDA; the full label on DailyMed
What does the ramelteon label say about doxepin?
Ramelteon label, drug interactionsIncreases systemic exposure of ramelteon; patients should be closely monitored when ramelteon is coadministered with doxepin.
Source: FDA drug label (Rozerem), Takeda Pharmaceuticals America, Inc., effective April 15, 2026 (SPL set 9de82310-70e8-47b9-b1fc-6c6848b99455), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Doxepin | Ramelteon | |
|---|---|---|
| Labeled for | Depression, Anxiety, Eczema (atopic dermatitis), Insomnia | Insomnia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0779 per capsule 10 mg capsule | $0.660 per tablet 8 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once