Prazosin and Digoxin Interaction
Drug interaction information between Prazosin and Digoxin.
Prazosin and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prazosin and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no evidence that these drugs cause problems when taken at the same time. They do not appear to affect each other's safety or effectiveness.
FDA Label Information
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Prazosin Also Interacts With
- Allopurinol minor
- Aspirin minor
- Diazepam minor
- Indomethacin minor
- Colchicine minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Prazosin + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Prazosin's 11. In the minor band specifically: Prazosin has 11 (also Allopurinol, Aspirin, Diazepam, Indomethacin); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Prazosin and Digoxin?
There is no evidence that these drugs cause problems when taken at the same time. They do not appear to affect each other's safety or effectiveness.
Digoxin carries more major-labeled pairs than Prazosin
SPL source-record counts only. This page's band is minor · classes on file: Prazosin (Alpha-1 Blocker); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Prazosin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Prazosin
- Allopurinol
- Aspirin
- Diazepam
- Indomethacin
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.