Prazosin and Indomethacin Interaction
Drug interaction information between Prazosin and Indomethacin.
Prazosin and Indomethacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prazosin and Indomethacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Based on limited clinical data, these drugs do not have a known harmful interaction. They appear to be compatible when taken together.
FDA Label Information
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Prazosin Also Interacts With
- Allopurinol minor
- Aspirin minor
- Diazepam minor
- Digoxin minor
- Colchicine minor
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Prazosin + Indomethacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Indomethacin has 35 labeled pairs on file vs Prazosin's 11. In the minor band specifically: Prazosin has 11 (also Allopurinol, Aspirin, Diazepam, Digoxin); Indomethacin has 30 (also Meloxicam, Aspirin, Diclofenac, Cyclosporine).
What mechanism field is on file for Prazosin and Indomethacin?
Based on limited clinical data, these drugs do not have a known harmful interaction. They appear to be compatible when taken together.
Indomethacin's labeled portfolio outnumbers Prazosin
SPL source-record counts only. This page's band is minor · classes on file: Prazosin (Alpha-1 Blocker); Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Prazosin
- Allopurinol
- Aspirin
- Diazepam
- Digoxin
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Diclofenac
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.