Prazosin and Indomethacin Interaction
Drug interaction information between Prazosin and Indomethacin.
Prazosin and Indomethacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prazosin and Indomethacin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Based on limited clinical data, these drugs do not have a known harmful interaction. They appear to be compatible when taken together.
What To Do
This combination is considered safe based on current information. No special monitoring or dose changes are usually necessary.
FDA Label Information
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Prazosin Also Interacts With
- Allopurinol minor
- Aspirin minor
- Diazepam minor
- Digoxin minor
- Colchicine minor
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Frequently Asked Questions
Can I take Prazosin and Indomethacin together?
This is a minor interaction. This combination is considered safe based on current information. No special monitoring or dose changes are usually necessary.
How serious is the interaction between Prazosin and Indomethacin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Prazosin and Indomethacin interact?
Based on limited clinical data, these drugs do not have a known harmful interaction. They appear to be compatible when taken together.
Understanding the Prazosin and Indomethacin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Prazosin belongs to the Alpha-1 Blocker class and Indomethacin belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Based on limited clinical data, these drugs do not have a known harmful interaction. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Prazosin has 11 total documented interactions on file in this dataset, and Indomethacin has 35. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: This combination is considered safe based on current information. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Prazosin or Indomethacin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.