Prazosin and Colchicine Interaction
Drug interaction information between Prazosin and Colchicine.
Prazosin and Colchicine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prazosin and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications do not seem to interfere with one another when used at the same time. No bad reactions have been reported in clinical experience so far.
FDA Label Information
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Prazosin Also Interacts With
- Allopurinol minor
- Aspirin minor
- Diazepam minor
- Digoxin minor
- Indomethacin minor
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Prazosin + Colchicine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Prazosin's 11. In the minor band specifically: Prazosin has 11 (also Allopurinol, Aspirin, Diazepam, Digoxin); Colchicine has 15 (also Estradiol, Diltiazem, Norethindrone, Ketoconazole).
What mechanism field is on file for Prazosin and Colchicine?
These medications do not seem to interfere with one another when used at the same time. No bad reactions have been reported in clinical experience so far.
Colchicine carries more major-labeled pairs than Prazosin
SPL source-record counts only. This page's band is minor · classes on file: Prazosin (Alpha-1 Blocker); Colchicine (Anti-Gout Agent).
Colchicine has 4 major-labeled pairs vs Prazosin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Prazosin
- Allopurinol
- Aspirin
- Diazepam
- Digoxin
4 major · 9 moderate · 15 minor · 28 total
- Other minor peers for Colchicine
- Estradiol
- Diltiazem
- Norethindrone
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.