Prazosin and Colchicine Interaction
Drug interaction information between Prazosin and Colchicine.
Prazosin and Colchicine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prazosin and Colchicine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These medications do not seem to interfere with one another when used at the same time. No bad reactions have been reported in clinical experience so far.
What To Do
You may take these two drugs together safely. Your doctor does not usually need to change your treatment plan for this combination.
FDA Label Information
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Prazosin Also Interacts With
- Allopurinol minor
- Aspirin minor
- Diazepam minor
- Digoxin minor
- Indomethacin minor
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
Can I take Prazosin and Colchicine together?
This is a minor interaction. You may take these two drugs together safely. Your doctor does not usually need to change your treatment plan for this combination.
How serious is the interaction between Prazosin and Colchicine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Prazosin and Colchicine interact?
These medications do not seem to interfere with one another when used at the same time. No bad reactions have been reported in clinical experience so far.
Understanding the Prazosin and Colchicine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Prazosin belongs to the Alpha-1 Blocker class and Colchicine belongs to the Anti-Gout Agent class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These medications do not seem to interfere with one another when used at the same time. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Prazosin has 11 total documented interactions on file in this dataset, and Colchicine has 28. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You may take these two drugs together safely. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Prazosin or Colchicine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.