Prazosin and Aspirin Interaction
Drug interaction information between Prazosin and Aspirin.
Prazosin and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prazosin and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Prazosin and aspirin do not have a known negative reaction when used together. They appear to work safely in the body without interfering with each other.
FDA Label Information
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Prazosin Also Interacts With
- Allopurinol minor
- Diazepam minor
- Digoxin minor
- Indomethacin minor
- Colchicine minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Prazosin + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Prazosin's 11. In the minor band specifically: Prazosin has 11 (also Allopurinol, Diazepam, Digoxin, Indomethacin); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Prazosin and Aspirin?
Prazosin and aspirin do not have a known negative reaction when used together. They appear to work safely in the body without interfering with each other.
Aspirin carries more major-labeled pairs than Prazosin
SPL source-record counts only. This page's band is minor · classes on file: Prazosin (Alpha-1 Blocker); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Prazosin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Prazosin
- Allopurinol
- Diazepam
- Digoxin
- Indomethacin
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.