digoxin vs prazosin
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Side-by-side comparison of digoxin and prazosin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Prazosin (Minipress) is a medicine that lowers your blood pressure. Lowering blood pressure helps prevent strokes and heart attacks.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Prazosin is used to treat high blood pressure. Lowering your blood pressure reduces your risk of serious heart problems. It can be used alone or with other blood pressure medicines. Managing high blood pressure should include healthy habits like diet and exercise.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Prazosin belongs to a class of drugs called alpha-1 blockers. It works by relaxing your blood vessels. This makes it easier for blood to flow through your body, which lowers blood pressure.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Dizziness
- • Headache
- • Drowsiness
- • Lack of energy
- • Weakness
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Nausea 361
- Headache 265
- Dizziness 263
- Anxiety 260
- Fatigue 257
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Prazosin can cause a sudden drop in blood pressure, especially when you first start taking it. This can make you feel dizzy or faint. To avoid this, take your first dose at bedtime. Be careful when standing up quickly.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if prazosin will harm your unborn baby. Talk to your doctor about the risks and benefits of taking prazosin while pregnant or breastfeeding.
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How to Read This digoxin vs prazosin Comparison
digoxin is classified in the Cardiac Glycoside drug class, while prazosin sits within the Alpha-1 Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while prazosin has 1,406. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to there is no evidence that these drugs cause problems when taken at the same time. they do not appear to affect each other's safety or effectiveness.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or prazosin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.