Prazosin and Diazepam Interaction
Drug interaction information between Prazosin and Diazepam.
Prazosin and Diazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prazosin and Diazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs have been used together without causing any harmful side effects. They do not seem to change how the other medication works in the body.
FDA Label Information
Drug Interactions Prazosin hydrochloride has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides– digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout– allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol ( see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories– propoxyphene, aspirin,...
Prazosin Also Interacts With
- Allopurinol minor
- Aspirin minor
- Digoxin minor
- Indomethacin minor
- Colchicine minor
Diazepam Also Interacts With
- Clonazepam moderate
- Fluoxetine moderate
- Mirtazapine moderate
- Raloxifene moderate
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Prazosin + Diazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diazepam has 26 labeled pairs on file vs Prazosin's 11. In the minor band specifically: Prazosin has 11 (also Allopurinol, Aspirin, Digoxin, Indomethacin); Diazepam has 22 (also Omeprazole, Ketoconazole, Fluvoxamine, Cimetidine).
What mechanism field is on file for Prazosin and Diazepam?
These two drugs have been used together without causing any harmful side effects. They do not seem to change how the other medication works in the body.
Diazepam's labeled portfolio outnumbers Prazosin
SPL source-record counts only. This page's band is minor · classes on file: Prazosin (Alpha-1 Blocker); Diazepam (Benzodiazepine).
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Prazosin
- Allopurinol
- Aspirin
- Digoxin
- Indomethacin
0 major · 4 moderate · 22 minor · 26 total
- Other minor peers for Diazepam
- Omeprazole
- Ketoconazole
- Fluvoxamine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.