Pramlintide and Repaglinide Interaction
Drug interaction information between Pramlintide and Repaglinide.
Pramlintide and Repaglinide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pramlintide and Repaglinide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Based on the provided text, pramlintide may decrease the blood-sugar-lowering effect of repaglinide. This can result in blood sugar levels that are higher than your target range.
FDA Label Information
Examples: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, nonsteroidal anti-inflammatory agents (NSAIDs), pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics Drugs That May Decrease the Blood Glucose Lowering Effect of Repaglinide Intervention: Repaglinide dose increases and increased frequency of glucose monitoring may be required when co-administered.
Pramlintide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Glulisine moderate
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Clonidine moderate
- Cyclosporine moderate
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Pramlintide + Repaglinide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Repaglinide has 22 labeled pairs on file vs Pramlintide's 13. In the minor band specifically: Pramlintide has 4 (also Fluoxetine, Atropine, Glimepiride); Repaglinide has 17 (also Albuterol, Fluoxetine, Montelukast, Ketoconazole).
What mechanism field is on file for Pramlintide and Repaglinide?
Based on the provided text, pramlintide may decrease the blood-sugar-lowering effect of repaglinide. This can result in blood sugar levels that are higher than your target range.
Repaglinide carries more major-labeled pairs than Pramlintide
SPL source-record counts only. This page's band is minor · classes on file: Pramlintide (Amylin Analog); Repaglinide (Meglitinide).
Repaglinide has 2 major-labeled pairs vs Pramlintide's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 4 minor · 13 total
- Other minor peers for Pramlintide
- Fluoxetine
- Atropine
- Glimepiride
2 major · 3 moderate · 17 minor · 22 total
- Other minor peers for Repaglinide
- Albuterol
- Fluoxetine
- Montelukast
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.