Pramlintide and Insulin Glargine Interaction
Drug interaction information between Pramlintide and Insulin Glargine.
Pramlintide and Insulin Glargine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pramlintide and Insulin Glargine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medications are used to lower blood sugar, so using them at the same time increases the risk of hypoglycemia.
FDA Label Information
7 DRUG INTERACTIONS Table 6 includes clinically significant drug interactions with BASAGLAR Table 6: Clinically Significant Drug Interactions with BASAGLAR Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents,...
Pramlintide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glulisine moderate
- Insulin Human/Insulin Isophane moderate
Insulin Glargine Also Interacts With
- Fluoxetine moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Frequently Asked Questions
What SPL severity band is on file for Pramlintide + Insulin Glargine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pramlintide has 13 labeled pairs on file vs Insulin Glargine's 11. In the moderate band specifically: Pramlintide has 9 (also Insulin Aspart, Insulin Degludec, Insulin Detemir, Insulin Glulisine); Insulin Glargine has 3 (also Fluoxetine, Octreotide).
What mechanism field is on file for Pramlintide and Insulin Glargine?
Both medications are used to lower blood sugar, so using them at the same time increases the risk of hypoglycemia.
Pramlintide's labeled portfolio outnumbers Insulin Glargine
SPL source-record counts only. This page's band is moderate · classes on file: Pramlintide (Amylin Analog); Insulin Glargine (Long-Acting Insulin).
0 major · 9 moderate · 4 minor · 13 total
- Other moderate peers for Pramlintide
- Insulin Aspart
- Insulin Degludec
- Insulin Detemir
- Insulin Glulisine
0 major · 3 moderate · 8 minor · 11 total
- Other moderate peers for Insulin Glargine
- Fluoxetine
- Octreotide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.