Pramlintide and Fluoxetine Interaction
Drug interaction information between Pramlintide and Fluoxetine.
Pramlintide and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pramlintide and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can change how your body handles sugar, making it more likely for your blood sugar to drop too low when taken with pramlintide.
FDA Label Information
7.4 Drugs Affecting Glucose Metabolism The following are examples of medications that may increase the susceptibility to hypoglycemia when administered with SYMLIN: anti-diabetic products, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, salicylates, somatostatin analogs, and sulfonamide antibiotics.
Pramlintide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Glulisine moderate
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Pramlintide + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Pramlintide's 13. In the minor band specifically: Pramlintide has 4 (also Atropine, Glimepiride, Repaglinide); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Pramlintide and Fluoxetine?
Fluoxetine can change how your body handles sugar, making it more likely for your blood sugar to drop too low when taken with pramlintide.
Fluoxetine carries more major-labeled pairs than Pramlintide
SPL source-record counts only. This page's band is minor · classes on file: Pramlintide (Amylin Analog); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Pramlintide's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 4 minor · 13 total
- Other minor peers for Pramlintide
- Atropine
- Glimepiride
- Repaglinide
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.