What the FDA labels say about taking them together
Fluoxetine and pramlintide
Pramlintide's FDA label of December 18, 2019 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name pramlintide. The pramlintide label: “… products, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, salicylates, somatostatin analogs, and sulfonamide antibiotics.”
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the pramlintide FDA label on DailyMed (effective December 18, 2019, AstraZeneca Pharmaceuticals LP).
What does the fluoxetine label say about pramlintide?
Fluoxetine's label (effective January 8, 2026) does not name pramlintide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the pramlintide label say about fluoxetine?
Pramlintide label, drug interactionsThe following are examples of medications that may increase the susceptibility to hypoglycemia when administered with SYMLIN: anti-diabetic products, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, salicylates, somatostatin analogs, and sulfonamide antibiotics.
Source: FDA drug label (SymlinPen), AstraZeneca Pharmaceuticals LP, effective December 18, 2019 (SPL set 4aea30ff-eb0d-45c1-b114-3127966328ff), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Pramlintide | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | Type 2 diabetes, Type 1 diabetes |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once