Pramlintide and Glimepiride Interaction
Drug interaction information between Pramlintide and Glimepiride.
Pramlintide and Glimepiride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pramlintide and Glimepiride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines lower blood sugar, so using them at the same time can make your blood sugar drop to unsafe levels.
FDA Label Information
The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly...
Pramlintide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Glulisine moderate
Glimepiride Also Interacts With
- Albuterol minor
- Fluoxetine minor
- Clonidine minor
- Olanzapine minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Pramlintide + Glimepiride?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glimepiride has 16 labeled pairs on file vs Pramlintide's 13. In the minor band specifically: Pramlintide has 4 (also Fluoxetine, Atropine, Repaglinide); Glimepiride has 16 (also Albuterol, Fluoxetine, Clonidine, Olanzapine).
What mechanism field is on file for Pramlintide and Glimepiride?
Both of these medicines lower blood sugar, so using them at the same time can make your blood sugar drop to unsafe levels.
Glimepiride's labeled portfolio outnumbers Pramlintide
SPL source-record counts only. This page's band is minor · classes on file: Pramlintide (Amylin Analog); Glimepiride (Sulfonylurea).
0 major · 9 moderate · 4 minor · 13 total
- Other minor peers for Pramlintide
- Fluoxetine
- Atropine
- Repaglinide
0 major · 0 moderate · 16 minor · 16 total
- Other minor peers for Glimepiride
- Albuterol
- Fluoxetine
- Clonidine
- Olanzapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.