Repaglinide and Ketoconazole Interaction
Drug interaction information between Repaglinide and Ketoconazole.
Repaglinide and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Repaglinide and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole stops the body from processing repaglinide normally, which can lead to higher amounts of the medicine in your blood.
FDA Label Information
Examples: Drugs that are known to inhibit CYP3A4 include antifungal agents (ketoconazole, itraconazole) and antibacterial agents (clarithromycin, erythromycin).
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Clonidine moderate
- Cyclosporine moderate
- Rifampin moderate
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Repaglinide + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Repaglinide's 22. In the minor band specifically: Repaglinide has 17 (also Albuterol, Fluoxetine, Montelukast, Olanzapine); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Repaglinide and Ketoconazole?
Ketoconazole stops the body from processing repaglinide normally, which can lead to higher amounts of the medicine in your blood.
Ketoconazole carries more major-labeled pairs than Repaglinide
SPL source-record counts only. This page's band is minor · classes on file: Repaglinide (Meglitinide); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Repaglinide's 2. This page itself is in the minor band, not the major band.
2 major · 3 moderate · 17 minor · 22 total
- Other minor peers for Repaglinide
- Albuterol
- Fluoxetine
- Montelukast
- Olanzapine
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.