Repaglinide and Fluoxetine Interaction
Drug interaction information between Repaglinide and Fluoxetine.
Repaglinide and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Repaglinide and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can increase the blood-sugar-lowering effects of repaglinide, which might cause your blood sugar to drop too low.
FDA Label Information
Examples: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, nonsteroidal anti-inflammatory agents (NSAIDs), pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics Drugs That May Decrease the Blood Glucose Lowering Effect of Repaglinide Intervention: Repaglinide dose increases and increased frequency of glucose monitoring may be required when co-administered.
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Clonidine moderate
- Cyclosporine moderate
- Rifampin moderate
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Repaglinide + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Repaglinide's 22. In the minor band specifically: Repaglinide has 17 (also Albuterol, Montelukast, Ketoconazole, Olanzapine); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Repaglinide and Fluoxetine?
Fluoxetine can increase the blood-sugar-lowering effects of repaglinide, which might cause your blood sugar to drop too low.
Fluoxetine carries more major-labeled pairs than Repaglinide
SPL source-record counts only. This page's band is minor · classes on file: Repaglinide (Meglitinide); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Repaglinide's 2. This page itself is in the minor band, not the major band.
2 major · 3 moderate · 17 minor · 22 total
- Other minor peers for Repaglinide
- Albuterol
- Montelukast
- Ketoconazole
- Olanzapine
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.