Repaglinide and Gemfibrozil Interaction
Drug interaction information between Repaglinide and Gemfibrozil.
Repaglinide and Gemfibrozil have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Repaglinide and Gemfibrozil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gemfibrozil stops your body from getting rid of repaglinide, which causes the level of repaglinide in your blood to become dangerously high.
Repaglinide Also Interacts With
- Clarithromycin major
- Clonidine moderate
- Cyclosporine moderate
- Rifampin moderate
- Albuterol minor
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Atorvastatin moderate
- Eluxadoline moderate
Frequently Asked Questions
What SPL severity band is on file for Repaglinide + Gemfibrozil?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Repaglinide has 22 labeled pairs on file vs Gemfibrozil's 20. In the major band specifically: Repaglinide has 2 (also Clarithromycin); Gemfibrozil has 4 (also Ezetimibe, Ezetimibe/Simvastatin, Simvastatin).
What mechanism field is on file for Repaglinide and Gemfibrozil?
Gemfibrozil stops your body from getting rid of repaglinide, which causes the level of repaglinide in your blood to become dangerously high.
Gemfibrozil carries more major-labeled pairs than Repaglinide
SPL source-record counts only. This page's band is major · classes on file: Repaglinide (Meglitinide); Gemfibrozil (Fibrate).
Gemfibrozil has 4 major-labeled pairs vs Repaglinide's 2.
2 major · 3 moderate · 17 minor · 22 total
- Other major peers for Repaglinide
- Clarithromycin
4 major · 8 moderate · 8 minor · 20 total
- Other major peers for Gemfibrozil
- Ezetimibe
- Ezetimibe/Simvastatin
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.